Applying your knowledge of immunology, analyse the causes of Essay

Applying your knowledge of immunology, analyse the causes of Cl.difficile. Discuss interventions for the prevention of Cl.difficile and the appropriate treatment for this infection - Essay ExampleC. difficile is a spore forming, anaerobic bacilli, shows positive Gram reaction and is know to be associated with nosocomial diarrhea. It is an etiological representative of pseudo membranous colitis (PMC) and 15-25% of diarrhea associated with the intake of antibiotics (Bartlett, 2002).It is known that bacteria adapt to the shifting environment and so do their response to antibiotics, making them resistant and more virulent. Severity of CDAD is also associated with similar paradigm. In fearsome and acute cases CDAD may cause ulceration and hemorrhage. The disease encompasses diarrhea, fever, amplified fecal leukocytes, abdominal cramping and dehydration leading to hypoalbuminaemia, toxic megacolon, colonic perforation and PMC causing amplification in morbidness and mortality (Poutanen, 20 04).Pathogenic Clostridium difficile gives exotoxins- A and B. They have potential role in causing CDAD (Pothoulakis, 1996). Strains producing toxin either A+ B+ or AB+ are responsible for virulence while non-toxin producing strains are non virulent and do not cause diarrhea.In normal individuals, enteric pathogens are prohibited from creation due to native intestinal microflora, contributing to hosts defense mechanism. Clostridium difficile is a potent pathogen that successfully establishes infection because of its immense ability to produce toxins thereby paving the way for C. difficile colonization. Toxins generated by C. difficile are highly enterotoxic and cytotoxic. Healthy individuals possess antibodies serum IgG and intestinal secretory IgA against toxin A, and efficiently restrict to the intestinal receptors of toxin A. This is a condition where humoural response to toxin A is hampered and thus C. difficile finds way for proliferation. The action of toxin A causes disrup tion of epithelial cells, enhanced fluid emission, damage of mucosa, indignation and tenderness due to enhanced permeability of tight junctions causing diarrhea or PMC